We introduce a new approach to defect engineering in Zr-based metal-organic frameworks (Zr-MOFs), aiming to reduce Zr site valency while preserving high node connectivity. Using a rapid heat treatment (RHT) in humid air, oxygen vacancies (O-vacancies) were created in Dresden University of Technology (DUT)-67 through cluster dehydration. Unlike conventional defect engineering, aimed at creating missing-linker defects, this method breaks intra-cluster Zr-μ3O–Zr bonds, generating coordinatively unsaturated Zr (Zrcus) sites.

Metalloproteins have evolved through the selective, strong, and precise interactions between metal ions and polypeptides. The coordination of metal ions to amino acid side chains is therefore a fundamental prerequisite for designing metalloproteins. Here, we present Metal-Installer, a user-friendly in silico tool that proposes probable mutation sites for metal ligation.

Background: Ovarian cancer presents with non-specific symptoms that make early diagnosis challenging and the prognosis poor. Ovarian and endometrial cancers exhibit similar genomic mutations and biomarker profiles. Endogenous volatile organic compounds (VOCs) are products of metabolic activity. In cancer, metabolites increase due to tumour necrosis, leading to cancer-specific VOC patterns. The aim of this study was to evaluate VOC analyses in plasma as diagnostic tests for early diagnosis of ovarian and endometrial cancer.

A variety of rotary molecular machine prototypes powered by light, chemical energy, or electrons have been synthesized and their operation in solution, gels, or on surfaces has been demonstrated. However, little data regarding their performances have been disclosed. Here, we report on the synthesis of molecules incorporating a five-arm rotor and the direct measurement of the work required to block the rotation around the central atom.

The bioorthogonal ligation between isonitriles and azomethine imines (AMIs)—the AMI-isonitrile ligation—combines exquisite chemoselectivity with a stable ligation product, a small molecular reporter, and a pH-dependent rate. In this work, we tailored the modular structure of the dipolar AMI to increase Brønsted basicity and electrophilicity. These additive structural modifications increased the ligation rate by more than two orders of magnitude to 14 M⁻¹s⁻¹ at pH 7, 140 M⁻¹s⁻¹ at pH 6, and >1,000 M⁻¹s⁻¹ at pH 5.

Decisions about which contraceptives to use are a key component of a couple's “fertility work,” and these decisions can be made in homogamous or heterogamous couple contexts. Relative resource theory and the strain perspective suggest that heterogamy may lead to differences in bargaining power or higher levels of discordance within couples, thereby affecting the distribution of fertility work and decisions about which contraceptives a couple will use.

Objectives: Lack of ethnic diversity in trials may contribute to health disparities and to inequity in health outcomes. The primary objective was to investigate the experiences and perspectives of ethnically diverse populations about how to improve ethnic diversity in trials. Study Design and Setting: Qualitative data were collected via 16 focus groups with participants from 21 ethnically diverse communities in Australia.

Introduction: Suboptimal cardiovascular health is associated with adverse pregnancy outcomes and long-term cardiovascular risk. The authors examined trends in cardiovascular risk factors and correlates of suboptimal cardiovascular risk profiles among reproductive-aged U.S. women.

Endometriosis is a burdensome gynaecological condition linked to the culturally variable concepts of menstruation and reproduction. Despite this, qualitative endometriosis research has been concentrated in high-income, anglophone countries. This systematic review and narrative synthesis primarily aimed to provide updated insights on endometriosis experiences, whilst secondarily investigating improvements in research diversity and reporting of socio-cultural experiences.

This research explores the dynamic intersection of gender, work, and national identity in the schooling process of primary school students during Spanish democracy through the school discourse (textual and iconographic) found in textbooks. Twelve textbooks from the period of the so-called transition period and the current decade are analyzed in order to identify changes and continuities in discursive practices throughout democracy. The methodological approach employed is Critical Discourse Analysis (CDA), incorporating various models of analysis.