This study reports the first use of BCMA-CD19 bispecific CAR-T cell therapy in a patient with refractory chronic inflammatory demyelinating polyneuropathy (CIDP), demonstrating significant clinical improvement and sustained remission without relapse after treatment, highlighting the potential of this novel approach for managing difficult-to-treat CIDP cases.

This study evaluated the behavioral, physiological, and molecular effects of social isolation (SI) in adult zebrafish, and whether the animals recover such changes after their reintroduction to the social environment. The results show that SI altered social behaviors, neural activity, and serotonergic and dopaminergic signaling in zebrafish, but these changes were reversed after the animals were reintroduced to a social context for 6 days.

This paper supports SDG 3 and 8 by examining firearm and non-firearm related suicide in current and former US service members.

This study examines the 6-year longitudinal associations between dietary patterns, intrinsic capacity (IC), and IC sub-domains in community-dwelling Korean older adults. The key findings are that in older men, the "variety of healthy foods and alcohols" dietary pattern was positively associated with changes in IC score, while in older women, the "variety of healthy foods" pattern was positively associated with changes in IC score, IC score group, and psychological domain.

This study investigates the relationship between antidiabetic drugs and Alzheimer’s disease (AD) in a population-based sample.

This review discusses the impact of Apolipoprotein-E4 (ApoE4) on cognitive performance in targeted-replacement human ApoE knock-in mice, finding that ApoE4 mice exhibit significant cognitive deficits compared to ApoE3 mice in various cognitive tests, indicating an intrinsic vulnerability in ApoE4 mice that may be exacerbated in the context of neurodegenerative diseases.

This study focuses on neuroimaging methods such as structural magnetic resonance imaging (sMRI) and fluorodeoxyglucose positron emission tomography (FDG-PET) have been used to diagnose and categorize AD

Dementia is a global leading cause of disability and death among older adults, and there is a need to carefully evaluate existing evidence on related risk factors to guide future research. This review summarized and evaluated the most updated evidence on associations of various magnesium forms (supplements, dietary intake, and biomarkers) with cognitive outcomes in adults, based on evidence from randomized controlled trials and cohort studies.